I use 48 grains of IMR 4227 powder with a 300 grain Hornady SST. I have a 150yd zero with 4" drop @ 200 yds. At 200 yds the bullet still smashes right throughthe deer, unfortunatly I have never recovered a bullet but they sure do perform good. I shot around 20 deer with that gun. Its my favorite gun but as bailey said just no follow up shot if need be. My 2nd favorite gun is my Savage Model 12 heavy bbl Varmiter in .22-250. It took a nice 6pt and 2 does last season by my brother in law.